PRESS RELEASE

Cambridge, MA, May 24, 2022Chroma Medicine, Inc., (Chroma) a genomic medicine company pioneering epigenetic editing therapeutics, today announced the appointment of George Golumbeski, Ph.D., former Executive Vice President of Business Development at Celgene, as an Independent Director and John Maraganore, Ph.D., former CEO of Alnylam, as a Strategic Advisor.

“We are thrilled to welcome George and John to the Chroma team. They are both remarkable pioneers in building leading biotechnology companies that have brought important innovative treatments to patients,” said Catherine Stehman-Breen, M.D., Chief Executive Officer of Chroma. “Their deep experience will be invaluable to Chroma and the Board during this period of growth, and I look forward to working closely with George and John as we realize Chroma’s mission of delivering precision cures for patients suffering from serious disease.”

Dr. Golumbeski brings more than 25 years of business development experience to the Board and has a track record of forging groundbreaking collaborations between biotech companies focused on delivering state-of-the-art medicines to patients.

“Epigenetic editing holds the potential to be transformative in the treatment of disease,” said Dr. Golumbeski. “I am eager to work with the Chroma team to help bring breakthrough therapeutics to patients with critical illnesses.”

Dr. Maraganore, a veteran in the biotech industry, brings decades of experience and scientific and strategic insight to his role. During his tenure at Alnylam, he led the company’s pioneering work in RNA interference from inception through global approval and commercialization of the first four novel RNAi therapeutics. He was also responsible for the company’s value creation strategy, raising over $7.5 billion and forming over 20 major pharmaceutical alliances.

“Chroma is well positioned to advance its pipeline of industry-leading epigenetic editors to durably and precisely control gene expression,” said Dr. Maraganore. “I am excited to provide strategic guidance to the leadership team and support the company’s ongoing development.”

About George Golumbeski, Ph.D.

Dr. Golumbeski is currently a Partner at DROIA Ventures and serves on the on the Board of several life sciences companies. Prior to this role, he led business development at Celgene, where he was responsible for strategic collaborations and acquisitions, product in- and out-licensing, and relationship management. Previously, he was Vice President of Business Development, Licensing, and Strategy at Novartis, and held leadership positions at several biotech and pharmaceutical companies, including Elan Pharmaceuticals and Schwarz Pharma. Dr. Golumbeski earned his Ph.D. in genetics/molecular biology from the University of Wisconsin-Madison and holds a B.A. in biology from the University of Virginia.

About John Maraganore, Ph.D.

At Alnylam, Dr. Maraganore guided the company’s strategy for pioneering RNA interference (RNAi) therapeutics, raising over $7.5 billion to support corporate growth and establishing strategic collaborations with leading global pharma companies—resulting in approval and commercialization of the world’s first RNAi medicines (ONPATTRO®, GIVLAARI®, OXLUMO®, and LEQVIO®). Previously, he served as Senior Vice President of Strategic Product Development at Millennium Pharmaceuticals, along with leadership roles at Biogen and Zymogenetics. Dr. Maraganore earned his Ph.D. in biochemistry and molecular biology from the University of Chicago, and serves on the Board of several professional organizations and biotech companies.

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About Chroma Medicine

Chroma Medicine is a biotechnology company pioneering a new class of genomic medicines that harness epigenetics, nature’s innate mechanism for gene regulation, to deliver new treatments for patients with genetically driven diseases. The company was founded by the world’s foremost experts in genomic research and is led by a veteran team of industry leaders and scientists with deep experience in genomic medicine, drug discovery, and development. For more information, please visit chromamedicine.com or follow the company on LinkedIn and Twitter.

Media Contact

Lia Dangelico
Verge Scientific Communications
540.303.0180
ldangelico@vergescientific.com

Cambridge, MA, November 17, 2021 – Chroma Medicine, Inc., (Chroma) a new genomic medicine company pioneering epigenetic editing, launched today with $125M in financing. Atlas Venture and Newpath Partners seeded the company with participation from Sofinnova Partners. The Series A was led by Cormorant Asset Management with participation by Casdin Capital, Janus Henderson Investors, Omega Funds, funds and accounts advised by T. Rowe Price Associates, Inc., and Wellington Management in addition to all seed investors.The financing will support continued development of the company’s epigenetic editing platform and advancement of its pipeline of targeted therapeutics.

Chroma has assembled a highly experienced team led by industry veterans Catherine Stehman-Breen, M.D., CEO, Vic Myer Ph.D., President and CSO, and Brett Kaplan, M.D., CFO. The company builds upon breakthrough epigenetic editing technologies developed by its scientific founders, Luke Gilbert, Ph.D., Keith Joung, M.D., Ph.D., David Liu, Ph.D., Angelo Lombardo, Ph.D., Luigi Naldini, M.D., Ph.D., and Jonathan Weissman, Ph.D.

“Epigenetic editing is the next frontier in genomic medicine with the potential to transform the treatment of genetically driven diseases. By harnessing nature’s innate mechanism to modulate gene expression, we can durably and precisely control gene expression without fundamentally changing or cutting the underlying DNA sequence,” said Dr. Stehman-Breen. “Supported by world-class founders and investors, the Chroma team is committed to deliver on the promise of this exciting platform.”

Chroma’s modular epigenetic editors can be precisely programmed to durably turn genes on or off or alter the expression of several genes at once. This approach represents a step change advance in gene editing, enabling the company to seamlessly silence, activate, and multiplex genes in a single platform. Chroma’s epigenetic editors have the potential to address a wide range of diseases and to become the technology of choice for gene regulation.

“Epigenetic editing provides fundamental mechanistic advantages over other genomic medicine approaches,” said Vic Myer, Ph.D. “First, by mimicking cells’ existing mechanism for regulating gene expression, it enables complete control of the target without activating unpredictable DNA repair pathways. Second, epigenetic editing opens the possibility of pursuing targets in the genome that are difficult to access with other therapeutic approaches, offering hope to patients suffering from serious illnesses.”

Chroma launches with partnerships with world-renowned academic institutions. Its recent acquisition of Milan, Italy-based Epsilen Bio seeded by Sofinnova Partners and founded by Angelo Lombardo, Ph.D. and Luigi Naldini, M.D., Ph.D., adds complementary capabilities through a partnership with the San Raffaele Telethon Institute for Gene Therapy, a joint institute between Ospedale San Raffaele and Fondazione Telethon, a pioneer in cell and gene therapy. The company also launches with collaborations with Massachusetts General Hospital and the University of California, San Francisco, global leaders in scientific innovation and genetic disease research.

“Chroma is building a next-generation technology platform of epigenetic editing tools,” said Bihua Chen, CEO and Portfolio Manager at Cormorant Asset Management. “This novel approach has the potential to address not only monogenic disease, but also complex diseases involving multiple genes that have long been out of reach of genomic editing. We believe the company is well-positioned to realize the potential of this exciting new technology.”

Chroma’s Board of Directors includes CEO Catherine Stehman-Breen, M.D. and investors Kevin Bitterman, Ph.D., Partner, Atlas Venture, Thomas Cahill, M.D., Ph.D., Managing Partner, Newpath Partners, Bihua Chen, CEO and Portfolio Manager, Cormorant Asset Management, and Paola Pozzi, Partner, Sofinnova Partners.

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About Chroma Medicine

Chroma Medicine is a biotechnology company pioneering a new class of genomic medicines that harness epigenetics, nature’s innate mechanism for gene regulation, to deliver new treatments for patients with genetically driven diseases. The company was founded by the world’s foremost experts in genomic research and is led by a veteran team of industry leaders and scientists with deep experience in genomic medicine, drug discovery, and development. For more information, please visit chromamedicine.com or follow the company on LinkedIn and Twitter.