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Boston, MA, September 3, 2024 – Chroma Medicine, Inc., (Chroma) a genomic medicine company pioneering single-course epigenetic editing therapeutics, presented new preclinical data demonstrating the potency, durability, and specificity of its PCSK9-targeted epigenetic editor in an oral presentation at the 2024 European Society of Cardiology Congress, held August 30-September 2 in London. The data showcase the potential best-in-class potency achievable in NHPs with Chroma’s optimized epigenetic editors. They also indicate the company’s epigenetic editing platform can effectively silence expression of PCSK9 in the liver, inducing durable reductions in low-density lipoprotein-cholesterol (LDL-C) levels without cutting or nicking the DNA. The PCSK9 gene actively promotes the degradation of…

Boston, MA, July 18, 2024 – Chroma Medicine, Inc., (Chroma) a genomic medicine company pioneering single-course epigenetic editing therapeutics, today announced the appointment of Melissa J. Moore, Ph.D., to its Board of Directors. “Melissa brings decades of experience directing RNA research and drug development at leading pharma companies and in academia,” said Catherine Stehman-Breen, M.D., CEO of Chroma. “Her deep knowledge will benefit us as we advance our platform of highly potent and durable epigenetic editors to patients, enabling a new class of genomic medicines.” Currently serving as a Board Director and Scientific Advisory Board member for multiple biotechnology companies, Dr. Moore…

Boston, MA, June 27, 2024 – Chroma Medicine, Inc. (Chroma) a genomic medicine company pioneering single-course epigenetic editing therapeutics, today announced it has entered into an exclusive license agreement with the Whitehead Institute to access intellectual property and technology developed in the lab of Chroma co-founder Jonathan Weissman, Ph.D.  The novel technology called CHARM (coupled histone tail for autoinhibition release of methyltransferase) uses a compact epigenetic editing effector domain to recruit and activate endogenous DNA methyltransferases to durably silence target genes. CHARM can utilize a self-silencing mechanism to limit its duration of expression and has been shown by Dr. Weissman’s lab to…

Boston, MA, May 20, 2024 – Chroma Medicine, Inc., (Chroma) a genomic medicine company pioneering single-course epigenetic editing therapeutics, today announced the appointment of Jenny Marlowe, Ph.D., as the Company’s Chief Development Officer. Dr. Marlowe is a seasoned biopharma executive and scientific leader with deep expertise in translational, preclinical development, and preclinical safety across multiple genomic medicine modalities.  “I am thrilled to welcome Jenny to Chroma,” said Catherine Stehman-Breen, M.D., CEO of Chroma. “Jenny joins our team at a pivotal time as we prepare to transition to the clinic. Her leadership, experience, and expertise will be instrumental as we work to bring…